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Phospho-ZIP7 (Ser275/276) Antibody | Gentaur

€340.00
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SKU:
796-AF3866-GEN
Availability:
IN STOCK
Size:
100 µg
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Product Description

Phospho-ZIP7 (Ser275/276) Antibody

Species Reactivity Human, Mouse

Host/Isotype Rabbit / IgG, kappa

Class Recombinant Monoclonal

Type Antibody

Clone Stat1S727-C6

Immunogen A synthetic phospho-peptide corresponding to residues surrounding Ser727 of human phospho Stat1.

Conjugate PE

Excitation/Emission Profile View spectra

Form Liquid Purification Protein A/G

Storage buffer PBS, pH 7.4, with 0.2% BSA

Contains 0.09% sodium azide

Storage conditions 2-8°C

RRID AB_2745057

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production.

The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism.

Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors.

After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

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