Swiss-Prot entry

AC O60741;
DT 28-FEB-2003 (Rel. 41, Created)
DT 28-FEB-2003 (Rel. 41, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated
DE channel 1 (Brain cyclic nucleotide gated channel 1) (BCNG-1).
GN Name=HCN1; Synonyms=BCNG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE OF 122-862, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX MEDLINE=98292171; PubMed=9630217 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/S0092-8674(00)81434-8;
RA Santoro B., Liu D.T., Yao H., Bartsch D., Kandel E.R.,
RA Siegelbaum S.A., Tibbs G.R.;
RT "Identification of a gene encoding a hyperpolarization-activated
RT 'pacemaker' channel of brain.";
RL Cell 93:717-729(1998).
CC -!- FUNCTION: Hyperpolarization-activated ion channel exhibiting weak
CC selectivity for potassium over sodium ions. Contributes to the
CC native pacemaker currents in heart (If) and in neurons (Ih).
CC Activated by cAMP, and at 10-100 times higher concentrations, also
CC by cGMP. May mediate responses to sour stimuli.
CC -!- SUBUNIT: The potassium channel is probably composed of a homo- or
CC heterotetrameric complex of pore-forming subunits. Heteromultimer
CC with HCN2 (By similarity). Interacts with KCNE2 (By similarity).
CC -!- SUBCELLULAR LOCATION: Integral membrane protein.
CC -!- TISSUE SPECIFICITY: Detected in brain, in particular in amygdala
CC and hippocampus, while expression in caudate nucleus, corpus
CC callosum, substantia nigra, subthalamic nucleus and thalamus is
CC very low or not detectable. Detected at very low levels in muscle
CC and pancreas.
CC -!- DOMAIN: The segment S4 is probably the voltage-sensor and is
CC characterized by a series of positively charged amino acids at
CC every third position.
CC -!- SIMILARITY: Belongs to the potassium channel family. HCN
CC subfamily.
CC -!- SIMILARITY: Contains 1 cyclic nucleotide-binding domain.
CC -!- CAUTION: This is a conceptual translation.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; AC114975; -; NOT_ANNOTATED_CDS; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AC099514; -; NOT_ANNOTATED_CDS; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF064876; AAC39759.1; ALT_TERM; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR SMR; O60741; 401-601.
DR Ensembl; ENSG00000164588; Homo_sapiens
DR HGNC; HGNC:4845; HCN1.
DR CleanEx; HGNC:4845; HCN1.
DR MIM; 602780; -. [NCBI / EBI]
DR GeneCards; HCN1.
DR GeneLynx; HCN1.
DR GenAtlas; HCN1.
DR SOURCE; HCN1.
DR GO; GO:0016021; C:integral to membrane; NAS.
DR GO; GO:0005267; F:potassium channel activity; NAS.
DR GO; GO:0006813; P:potassium ion transport; NAS.
DR InterPro; IPR000595; cNMP_binding.
DR InterPro; IPR003938; EAG_ELK_ERG.
DR InterPro; IPR005821; Ion_trans.
DR InterPro; IPR001622; K+channel_pore.
DR InterPro; IPR005820; M+channel_nlg.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; FALSE_NEG.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR CMR; O60741.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain]
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; O60741.
DR ProtoNet; O60741.
DR ProtoMap; O60741.
DR PRESAGE; O60741.
DR DIP; O60741.
DR ModBase; O60741.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW cAMP; cAMP-binding; Glycoprotein; Ion transport; Ionic channel;
KW Nucleotide-binding; Potassium; Potassium channel; Potassium transport;
KW Sodium; Sodium channel; Sodium transport; Transmembrane; Transport;
KW Voltage-gated channel.
FT TOPO_DOM 1 146 Cytoplasmic (Potential).
FT TRANSMEM 147 167 Segment S1 (Potential).
FT TRANSMEM 174 194 Segment S2 (Potential).
FT TOPO_DOM 195 219 Cytoplasmic (Potential).
FT TRANSMEM 220 240 Segment S3 (Potential).
FT TRANSMEM 249 269 Segment S4 (Potential).
FT TOPO_DOM 270 300 Cytoplasmic (Potential).
FT TRANSMEM 301 321 Segment S5 (Potential).
FT TRANSMEM 345 366 Segment H5 (pore-forming) (Potential).
FT TRANSMEM 372 392 Segment S6 (Potential).
FT TOPO_DOM 393 890 Cytoplasmic (Potential).
FT NP_BIND 475 592 cAMP.
FT REGION 89 140 Involved in subunit assembly (By
FT similarity).
FT COMPBIAS 1 80 Gly-rich.
FT COMPBIAS 726 756 Gln-rich.
FT COMPBIAS 857 863 Poly-Pro.
FT CARBOHYD 338 338 N-linked (GlcNAc...) (Potential).
FT CONFLICT 841 841 L -> F (in Ref. 2).
FT CONFLICT 857 857 P -> L (in Ref. 2).
FT CONFLICT 861 861 P -> L (in Ref. 2).
SQ SEQUENCE 890 AA; 98929 MW; 4B1B8511369EDDE6 CRC64;
MEGGGKPNSS SNSRDDGNSV FPAKASATGA GPAAAEKRLG TPPGGGGAGA KEHGNSVCFK
VDGGGGGGGG GGGGEEPAGG FEDAEGPRRQ YGFMQRQFTS MLQPGVNKFS LRMFGSQKAV
EKEQERVKTA GFWIIHPYSD FRFYWDLIML IMMVGNLVII PVGITFFTEQ TTTPWIIFNV
ASDTVFLLDL IMNFRTGTVN EDSSEIILDP KVIKMNYLKS WFVVDFISSI PVDYIFLIVE
KGMDSEVYKT ARALRIVRFT KILSLLRLLR LSRLIRYIHQ WEEIFHMTYD LASAVVRIFN
LIGMMLLLCH WDGCLQFLVP LLQDFPPDCW VSLNEMVNDS WGKQYSYALF KAMSHMLCIG
YGAQAPVSMS DLWITMLSMI VGATCYAMFV GHATALIQSL DSSRRQYQEK YKQVEQYMSF
HKLPADMRQK IHDYYEHRYQ GKIFDEENIL NELNDPLREE IVNFNCRKLV ATMPLFANAD
PNFVTAMLSK LRFEVFQPGD YIIREGAVGK KMYFIQHGVA GVITKSSKEM KLTDGSYFGE
ICLLTKGRRT ASVRADTYCR LYSLSVDNFN EVLEEYPMMR RAFETVAIDR LDRIGKKNSI
LLQKFQKDLN TGVFNNQENE ILKQIVKHDR EMVQAIAPIN YPQMTTLNST SSTTTPTSRM
RTQSPPVYTA TSLSHSNLHS PSPSTQTPQP SAILSPCSYT TAVCSPPVQS PLAARTFHYA
SPTASQLSLM QQQPQQQVQQ SQPPQTQPQQ PSPQPQTPGS STPKNEVHKS TQALHNTNLT
REVRPFSAWQ PSLPHEVSTL ISRPHPTVGE SLASIPQPVT AVPGTGLQAG GRSTVPQRVT
LFRQMSSGAI PPNRGVPPAP PPPAAALPRE SSSVLNTDPD AEKPRFASNL

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