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PrionDB: Automated extraction
PrionDB: Automated extraction of point mutations from the literature
This section provides point mutations extracted from the literature in an automatic manner
Point mutations (PMs) were extracted using an algorithm named 'MuteXt' (Horn et al. 2004). MuteXt extracts PMs from full text papers (or Medline abstracts when full texts are not accessible).
MuteXt does not distinguish 1)single PMs (e.g. F234H) from multiple PMs (e.g. F234H/F255C/G277V); 2) PMs that are described by the authors from PMs that are only cited and published elsewhere. MuteXt misses PMs that are described in figures and PMs with a too funny nomenclature (e.g. FH234, H234 instead of F234H).
Residue numbering: All the point mutations are numbered using the Swiss-Prot residue numbering. When appropriate, the authors' numbering is indicated in the pages that describe individual point mutations.
Access the data via
The list of extracted point mutations
The list of receptors
A simple query system