Antibodies that detect ACE2 can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry, ELISA and Flow Cytometry.
These antibodies target ACE2 in Human, Rat, Mouse and Porcine samples. Our ACE2 monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Goat. These antibodies have been verified by Relative expression to confirm specificity to ACE2.
Angiotensin converting enzyme 2 (ACE-2), also known as ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase.
ACE-2 also serves as the receptor for the SARS-CoV and SARS-CoV-2 viruses. Binding of the S1 domain of the SARS Coronavirus Spike protein to ACE-2 initiates viral entry into the host cell. Recently, this interaction between SARS-CoV-2 and ACE-2 has become an area of intense therapeutic interest to develop treatments against COVID-19.
